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What are synthetic cannabinoids? Synthetic cannabinoids are functionally similar to Δ9-tetrahydrocannabinol (THC), the active principle of cannabis.Like THC, they bind to the same cannabinoid receptors in the brain and other organs as the endogenous ligand anandamide. How do synthetic cannabinoids affect the brain? synthetic cannabinoids on the same brain cell receptors as THC (delta-9-tetrahydrocannabinol), the mind-altering ingredient in marijuana.
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